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Learn About Microbiology

What is the Difference Between Gram Positive and Gram Negative Bacteria?

Written by Jason Williams, B.S.

The main difference between gram negative and gram positive bacteria has to do with the arrangement of the outer portions of the cell.

The two illustrations that follow represent cross-sections of the cell wall and cell membrane of gram positive bacteria and gram negative bacteria, respectively.

Gram Positive Bacterium

Gram Negative Bacterium